Currently, uric acid disorders, especially including hyperuricosuria, are thought to be important in the formation Of idiopathic calcium urolithiasis.
Herein, we estimated the serum concentration and urinary excretion of uric acid in I22 stone-formers, comparing to those in 56 controls. Also, various theories about the pathogenesis of uric acid disorder and stone formation were discussed.
The results were as follows:
1. Serum uric acid levels of stone-formers were significantly higher than those of controls, in total and female, but, not in male.
2. Urinary uric acid levels of stone-formers were significantly higher than those of controls in total, male and female.
3. Hyperuricemia was significantly more frequent for stone-formers in total, male and female.
4. Hyperuricosuria was significantly more frequent for stone-formers in total, but, not significantly more frequent for stone-formers in male and female.
5. The incidence of stone-formers, in whom hyperuricemia and hyperuricosuria were not present at the sometime, was significantly less than that Of controls.
These results suggest the possibility that uric acid disorder may play some roles in the genesis of urinary stone.
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